Mouse Antibody

来自 : 发布时间：2024-05-12

AbstractThe article addresses many questions related to mouse antibodies, antibody isotypes and isotyping, and antibody molecular weight. Mouse antibody isotypes/classes, subclasses and mouse antibody isotypingThere are five antibody isotypes (IgA, IgD, IgE, IgG, and IgM) from mice, same as humans. Each isotype has a different heavy chain. Isotypes are also called classes. Another name for antibodies is immunoglobulin, hence the suffix of \'Ig\' to designate antibody classes and subclasses. Naive B cells produce IgM and IgD. During B cell maturation, through isotypic switching, a mature B cell will produce one of IgG, or IgA, or IgE isotypes and subclasses. Different isotypes have different half-lives in vivo, ranging from 12 hours to 8 days [1]. Figure 1. BALB/c mouse, a common mouse strain for mouse monoclonal antibody development. Courtesy of The Jackson LaboratoryMouse isotype genes Each heavy chain is formed by variable and constant regions. The constant regions have been designated as distinct genes, although they only form part of the immunoglobulin heavy chain. Table 1 lists mouse antibody classes, subclasses, gene names, and links to NCBI and IMGT gene databases. IsotypesSubclassesNCBI geneIMGT geneIgA IGHA IgD 380797 IGHD IgE IGHE IgG IgG1 16017 IGHG1 IgG2a 380793 IGHG2A IgG2b 16016 IGHG2B IgG2c 404711 IGHG2C IgG3 IGHG3 IgM 16019 IGHM Table 1. Mouse isotypes/classes, subclasses and their genes. For IgG2a and IgG2c isotypes: inbred mouse strains with the Igh1-b allele have IgG2c isotype instead of IgG2a [2]. The murine heavy chain locus has only one of these two isotype genes in addition to the other isotypes. Figure 2. IgG, IgE, IgD, IgM, and IgA schematic representations. Mouse antibody isotypes in Labome antibody databaseLabome antibody database organizes antibody products from over 100 high-quality suppliers. Many of them provide monoclonal antibodies generated from mice. Table 2 list a few examples of commercial antibodies, indicating antibodies are available with different isotypes.IsotypeExamplesIgA CD36, Sm proteins IgE ovalbumin, CD3 IgG1 cytokeratin, TLR4/MD-2 IgG2a Toxoplasma gondii, CD45, GATA-4 IgG2b histone H3, FAM3B, PD-L1 IgG2c CD209a IgG3 cadherin, cortisol IgM CD15 Table 2. Examples of research antibody reagents with different mouse isotypes.Human, mouse, rabbit, and other animals have different sets of isotype and subclass genes. Table 3 lists the different sets of isotype and subclass genes in some of the commonly used animal species in laboratories. IgG2a is absent in certain mouse strainslike C57BL, SJL, and NOD mice, which have IgG2c [3]. SpeciesIsotypesmouse IgA IgD IgE IgG1, IgG2a/IgG2c, IgG2b, IgG3 IgM Norwegian rat IgAIgDIgEIgG1, IgG2a, IgG2b, IgG2cIgM human IgA1, IgA2 IgDIgEIgG1, IgG2, IgG3, IgG4IgM rabbit IgA1, IgA2, IgA3, ... IgEIgGIgM goat IgAIgEIgG1, IgG2IgEIgM chicken IgY Table 3. Different animal species have different sets of antibody isotypes and subclass genes. The importance of antibody isotypesAntibody isotypes in vivo are very important in immune responses and effector mechanism. Mouse IgG isotypes are important to the biological functions of the immunoglobulin in vivo as well. Mouse IgG isotypes displayed marked differences in bactericidal (IgG3 >> IgG2b > IgG2a >> IgG1) and opsonophagocytic (IgG3 > IgG2b = IgG2a >> IgG1) activity when reacting with the P1.16 epitope on the outer membrane PorA protein of Neisseria meningitidis [4]. The establishment of mouse gut microbiome is likely enabled through mucosal IgA [5]. Human IgG subclasses differ in the size of their hinge regions and display different levels of spatial tolerance for the bivalent binding, with IgG3 having the longest amino acid hinge region and exhibiting the most flexible bivalent binding [6]. Human IgG1 to IgG4 subclasses are named after their serum prevalence [7]. Most antibody users seem to be not particular about the antibody classes and subclasses, this is especially true in western blot and immunoprecipitation. However in double labeling experiments and flow cytometry runs, such as in the case of secondary antibodies, the classes/subclasses should be considered (see Labome secondary antibody review for an in-depth discussion). As a side note, a number of monoclonal antibody therapeutics such as Eculizumab and Pembrolizumab are human IgG4 (mouse does not have IgG4 isotype). Maun HR et al, for example, humanized mouse and rabbit anti-tryptase variants as IgG4 antibodies [8]. Compared to IgG1-3, IgG4 Fc does not activate complement cascade, and binds to Fc receptor with intermediate affinity. Its unique structural properties have been identified [9]. In addition, increased concentrations of human serum IgG4 are associated with specific diseases such as autoimmune pancreatitis [10]. Complement activation can also be minimized through specific mutations in IgG1 [11]. Method Supplier Catalog number Sample reference block/activate Invitrogen 16-0037-85 [12, 13] block/activate Bio X Cell BE0036-5MG [14, 15] block/activate BioLegend 302902 [16, 17] block/activate R&D Systems MAB17781 [18, 19] block/activate Abcam ab17044 [20, 21] block/activate Santa Cruz Biotechnology sc-6251 [22, 23] ChIP Abcam ab1220 [24, 25] ChIP MilliporeSigma F1804 [26, 27] ChIP Santa Cruz Biotechnology sc-126 [28, 29] ChIP Novus Biologicals NB100-124 [30, 31] ChIP Active Motif 39097 [32, 33] ChIP BioLegend 664906 [34, 35] ChIP Invitrogen MA1-12692 [32, 36] ChIP R&D Systems PP-A8620A-00 [37, 38] ChIP-Seq Abcam ab1220 [39, 40] ChIP-Seq MilliporeSigma F1804 [41, 42] ChIP-Seq BioLegend 664906 [43, 44] ChIP-Seq Bio-Rad MCA1360 [45, 46] ChIP-Seq Santa Cruz Biotechnology sc-126 [47, 48] ELISA Invitrogen M700A [49, 50] ELISA BioLegend 803017 [51, 52] ELISA MABTECH 3420-3-1000 [53, 54] ELISA Bio-Rad MCA1659 [55, 56] ELISA Hytest 4C28-C2 [57, 58] ELISA Santa Cruz Biotechnology sc-136468 [59, 60] ELISA Abcam ab66189 [61, 62] ELISA Abnova H00007178-M06 [63, 64] ELISA Enzo Life Sciences ALX-801-090-1 [65, 66] ELISA MilliporeSigma A8354 [67, 68] ELISA R&D Systems MAB2814 [69, 70] ELISA Sino Biological 11973-MM05T-H [71, 72] EMSA MilliporeSigma F1804 [27, 73] EMSA Santa Cruz Biotechnology sc-8008 [74, 75] FC BioLegend 109843 [76, 77] FC Invitrogen 14-5825-82 [78, 79] FC Miltenyi Biotec 130-090-422 [80, 81] FC Santa Cruz Biotechnology sc-5279 [82, 83] FC Enzo Life Sciences ALX-804-806-C100 [84, 85] FC R&D Systems FAB6561P [86, 87] FC MilliporeSigma A2547 [88, 89] FC Novus Biologicals NB600-235 [90, 91] FC Abcam ab10214 [92, 93] FC Bio-Rad MCA1774GA [94, 95] FC Bio X Cell BE0036-5MG [15, 96] FC LifeSpan Biosciences LS-B2237 [97, 98] FC MABTECH 3465-7 [99, 100] FC StressMarq Biosciences SMC-154D [101, 102] FC Synaptic Systems 311 011 [92, 103] IC Santa Cruz Biotechnology sc-5279 [104, 105] IC BioLegend 801202 [106, 107] IC MilliporeSigma T6557 [108, 109] IC Invitrogen 33-9100 [110, 111] IC Abcam ab7817 [112, 113] IC R&D Systems MAB2018 [114, 115] IC Synaptic Systems 104 211 [116, 117] IC Enzo Life Sciences BML-PW8810-0100 [118, 119] IC LifeSpan Biosciences LS-C49111 [120, 121] IC Novus Biologicals NB100-105 [122, 123] IC Bio-Rad MCA5780GA [124, 125] IC Abnova H00001070-M01 [126, 127] IC Active Motif 61017 [115, 128] IC GeneTex GTX70212 [129, 130] IC ImmunoStar 22941 [131, 132] IC Miltenyi Biotec 130-090-422 [133, 134] IC Rockland Immunochemicals 200-301-400 [135, 136] IC MyBioSource MBS120432 [137, 138] IC Alomone Labs ALM-051 [139, 140] IC OriGene TA150041 [141, 142] IC StressMarq Biosciences SMC-140D [143, 144] IHC Invitrogen MN1020 [145, 146] IHC MilliporeSigma G3893 [147, 148] IHC BioLegend 801201 [149, 150] IHC ImmunoStar 22941 [151, 152] IHC Santa Cruz Biotechnology sc-56 [153, 154] IHC Bio-Rad MCA341R [155, 156] IHC Abcam ab51502 [157, 158] IHC Novus Biologicals NB100-105 [159, 160] IHC Synaptic Systems 131 011 [161, 162] IHC Enzo Life Sciences ADI-VAM-PS003-F [163, 164] IHC Dianova DIA-H09 [165, 166] IHC R&D Systems MAB1195 [167, 168] IHC GeneTex GTX71935 [169, 170] IHC LifeSpan Biosciences LS-C18692 [171, 172] IHC Active Motif 39763 [173, 174] IHC OriGene TA503316 [80, 175] IHC Sino Biological 10084-MB55 [176, 177] IHC-F BioLegend 801202 [178, 179] IHC-F MilliporeSigma G3893 [180, 181] IHC-F Invitrogen A-21271 [182, 183] IHC-F Abcam ab51502 [184, 185] IHC-F Bio-Rad MCA341R [186, 187] IHC-F ImmunoStar 22941 [188, 189] IHC-F Synaptic Systems 147 011 [190, 191] IHC-F Enzo Life Sciences ADI-VAM-PS003-D [192, 193] IHC-F LifeSpan Biosciences LS-C49111 [194, 195] IHC-F Santa Cruz Biotechnology sc-32251 [196, 197] IHC-F R&D Systems MAB1195 [198, 199] IHC-F Abnova H00001406-M02 [200, 201] IHC-F Novus Biologicals NB100-132 [202, 203] IHC-Free Invitrogen MN1020 [204, 205] IHC-Free MilliporeSigma G3893 [206, 207] IHC-Free BioLegend 803001 [208, 209] IHC-Free ImmunoStar 22941 [210, 211] IHC-Free Abcam ab51502 [212, 213] IHC-Free Santa Cruz Biotechnology sc-17839 [214, 215] IHC-Free Synaptic Systems 131 011 [216, 217] IHC-Free Bio-Rad MCA341GA [218, 219] IHC-P MilliporeSigma A2547 [220, 221] IHC-P Invitrogen MN1020 [222, 223] IHC-P Abcam ab20034 [224, 225] IHC-P Bio-Rad MCA341R [226, 227] IHC-P Novus Biologicals NB100-105 [228, 229] IHC-P Santa Cruz Biotechnology sc-56 [230, 231] IHC-P BioLegend 803001 [232, 233] IHC-P Dianova DIA-H09 [234, 235] IHC-P R&D Systems MAB1420 [236, 237] IHC-P Abnova H00029978-M03 [238, 239] IHC-P Enzo Life Sciences BML-PW8810-0100 [240, 241] IHC-P Miltenyi Biotec 130-090-422 [242, 243] IHC-P Active Motif 39649 [244, 245] IHC-P GeneTex GTX20029 [246, 247] IHC-P ImmunoStar 22941 [248, 249] IHC-P LifeSpan Biosciences LS-B6138 [250, 251] IHC-P OriGene CF500641 [252, 253] IP MilliporeSigma F1804 [254, 255] IP Santa Cruz Biotechnology sc-40 [256, 257] IP Invitrogen R960-25 [258, 259] IP BioLegend 901503 [260, 261] IP Abcam ab18181 [262, 263] IP Novus Biologicals NB100-105 [264, 265] IP Enzo Life Sciences ADI-SPA-830-D [266, 267] IP OriGene TA50011-100 [268, 269] IP Abnova H00001859-M01 [270, 271] IP Bio-Rad MCA1396 [272, 273] IP LifeSpan Biosciences LS-C103482 [274, 275] IP R&D Systems MAB25031 [276, 277] PLA BioLegend 802801 [278, 279] PLA MilliporeSigma T6199 [280, 281] PLA OriGene TA800301 [282, 283] PLA Santa Cruz Biotechnology sc-56 [284, 285] RIP Abcam ab56919 [286, 287] RIP Invitrogen 32-4800 [288, 289] RIP MilliporeSigma F1804 [290, 291] RIP Santa Cruz Biotechnology sc-32301 [292, 293] WB MilliporeSigma A5441 [294, 295] WB Santa Cruz Biotechnology sc-47778 [296, 297] WB Abcam ab8245 [298, 299] WB Invitrogen AM4300 [300, 301] WB Novus Biologicals NB100-105 [302, 303] WB BioLegend 803001 [304, 305] WB HUABIO EM21002 [306, 307] WB Enzo Life Sciences BML-PW8810-0100 [308, 309] WB Abnova H00008878-M01 [310, 311] WB Synaptic Systems 104 211 [312, 313] WB GeneTex GTX627408 [314, 315] WB Bio-Rad MCA1360 [316, 317] WB StressMarq Biosciences SMC-100B [318, 319] WB R&D Systems MAB1536 [320, 321] WB Miltenyi Biotec 130-092-395 [322, 323] WB Rockland Immunochemicals 200-301-400 [324, 325] WB Active Motif 39763 [326, 327] WB OriGene TA50011-100 [328, 329] WB EnCor Biotechnology MCA-1D4 [330, 331] WB Hytest 5G4-6C5 [332, 333] WB ImmunoStar 22941 [334, 335] WB Sino Biological 100005-MM01 [336, 337] WB LifeSpan Biosciences LS-B4372 [338, 339] Table 4. The most cited mouse monoclonal antibodies from different suppliers for different immunological methods and their references, based on a survey of formal publications in Labome\'s Validated Antibody Database, as of April 20, 2021. Publications are limited to those published since 2014. Only one mouse monoclonal antibody from each supplier is listed for each method. Mouse antibody isotypingThe isotype and subclass for a mouse antibody can be determined by specific anti-heavy chain constant region antibodies, usually through ELISA or flow cytometry, with appropriate isotype controls. These isotyping kits are available in different formats from many different suppliers. One of the most cited isotyping kits in the literature is AbDSerotec MMT1, see the isotyping kit. Mouse antibody molecular weightAn immunoglobulin molecule has two heavy chains and two light chains, linked together with intrachain and interchain disulfide bonds (with exceptions). In human IgA2, the heavy and light chains are not linked with disulfide bonds. Heavy chains for IgA, IgD, and IgG have a constant region with three immunoglobulin (Ig) domains. For example, mouse IgA heavy chain constant region has 344 amino acid, and mouse IgG1 constant region has 324 amino acids. Other types of heavy chains may have a different number of immunoglobulin domains. For example, secreted and membrane-bound IgD heavy chain constant regions have two Ig domains (see Uniprot P01881 and P01882). Heavy chains for IgE and IgM have a constant region with four immunoglobulin domains. Mouse IgM heavy chain constant region has 475 amino acids. Heavy chains from all isotypes have a variable region with a single immunoglobulin domain. Each immunoglobulin domain is about 110 amino acid long. Each IgD and IgG heavy chain is about 450 amino acids, and each IgE and IgM heavy chain is about 550 amino acids. Each light chain (either kappa or lambda) has one constant immunoglobulin domain and one variable immunoglobulin domain, and is about 211 to 217 amino acids. The common IgG isotypes have a molecular weight of 150 KD. Under the reducing condition, each heavy chain is about 50 KD and each light chain is about 25 KD. IgM tends to exist in pentamer or hexamer form, where IgM molecules are covalently linked through disulfide bonds, which give rise to a molecular weight of 970 KD. Since immunoglobulins are glycosylated, the apparent molecular weights may differ, sometimes significantly, from the nominal molecular weights. Mouse antibody production The mouse is the predominant animal host for monoclonal antibody production and also a host for polyclonal antibody generation. While typical mouse monoclonal antibody production involves immunizing mice (often BALB/c mice, for example [340, 341] ) with foreign antigens along with the commonly used Freund adjuvant [340] or the new, water-soluble QuickAntibody [342], mouse monoclonal hybridoma can also be obtained directly by fusion of unimmunized spleen cells from a specific mouse strain with auto-antibodies, as in the case of anti-SM Y12 antibodies [343]. Other strains such as C57BL/6 [340, 344], NMRI, C3H, and SJL, and other adjuvants like Chitosan, LQ, or incomplete Freund\'s adjuvant, and evan cells overexpressing an immunogen [344], can also be used [345]. Genetically engineered mouse strain can also be used as the host to develop specific antibodies, for example, an IgG monoclonal antibody with high binding specificity against GM3 ganglioside was developed through beta3Gn-T5 knockout mice [346]. As of April 20, 2021, Labome database lists 259335 mouse monoclonal antibodies against 12100 human genes, 7227 mouse genes, 6522 rat genes and a total of 11209 genes from other 153 species. Please note, due to rebranding (see a discussion about rebranding here), other databases may cite higher available numbers. However, Labome has the only database that strives to reduce the number of rebranded antibody products. For any antibody not available from suppliers or researchers, companies or core laboratories, for example, Antibody Production Services (APS Ltd) [344] and Innovagen [347], can custom-produce as fee-for-service. Labome surveys the literature to develop Validated Antibody Database. Table 4 lists some of the most commonly cited mouse monoclonal antibodies among the articles Labome has curated. The most cited mouse antibody is likely to be the actin clone AC-15, which is commonly used as a western blot loading control. Anti-mouse gene antibodiesThe mouse is also a widely used research model, and many antibodies against mouse genes are available. As of April 20, 2021, Labome antibody database lists 107373 monoclonal antibodies against 8662 mouse genes, and 102172 polyclonal antibodies against 13566 mouse genes (see a summary of antibodies against mouse genes).Antibodies against all these genes can be searched and compared at Labome website, for example, antibodies against mouse p53, mouse albumin, mouse cd31, mouse cd20, and mouse c-myc. Anti-mouse secondary antibodiesMost monoclonal antibodies are generated in mice. It is common to use anti-mouse secondary antibodies. Labome survey on secondary antibodies indicates that goat anti-mouse secondary antibodies are the most common choices. On the right panel of that webpage, you can see links to secondary antibodies against different mouse isotypes and light chains. A point of concern is when a mouse antibody and an anti-mouse secondary antibody are used on mouse tissues. The secondary antibody tends to also recognize endogenous mouse immunoglobulins and generates a high background. This endogenous immunoglobulins should be blocked and saturated by a block reagent, such as an F(ab) fragment of an anti-mouse secondary antibody. Commercial kits, like \"Mouse on Mouse” Blocking Reagent from Vector Laboratories (MKB-2213 [348] or BMK-2202 [349] ) or AffiniPure Fab fragment Donkey antimouse IgG from Biozol (JIM-715-007-003) [340], can accomplish this. Humanized antibodies from transgenic miceOne of the important methods for generating humanized antibodies is through the immunization of transgenic mice with part of a human immunoglobulin genomic sequence. The entire human immunoglobulin variable-gene repertoire has been inserted into the mouse genome, enabling the generation of monoclonal antibodies with fully humanized variable regions [350], and in Regeneron VelocImmune mice [351, 352]. ReferencesVieira P, Rajewsky K. The half-lives of serum immunoglobulins in adult mice. Eur J Immunol. 1988;18:313-6 pubmedMartin R, Brady J, Lew A. The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice. J Immunol Methods. 1998;212:187-92 pubmedZhang Z, Goldschmidt T, Salter H. Possible allelic structure of IgG2a and IgG2c in mice. Mol Immunol. 2012;50:169-71 pubmed publisherMichaelsen T, Kolberg J, Aase A, Herstad T, Høiby E. The four mouse IgG isotypes differ extensively in bactericidal and opsonophagocytic activity when reacting with the P1.16 epitope on the outer membrane PorA protein of Neisseria meningitidis. Scand J Immunol. 2004;59:34-9 pubmedDonaldson G, Ladinsky M, Yu K, Sanders J, Yoo B, Chou W, et al. Gut microbiota utilize immunoglobulin A for mucosal colonization. Science. 2018;360:795-800 pubmed publisherShaw A, Hoffecker I, Smyrlaki I, Rosa J, Grevys A, Bratlie D, et al. Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies. Nat Nanotechnol. 2019;14:184-190 pubmed publisherCrowley A, Ackerman M. Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function. Front Immunol. 2019;10:697 pubmed publisherMaun H, Jackman J, Choy D, Loyet K, Staton T, Jia G, et al. An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell. 2019;179:417-431.e19 pubmed publisherDavies A, Rispens T, Ooijevaar de Heer P, Gould H, Jefferis R, Aalberse R, et al. Structural determinants of unique properties of human IgG4-Fc. J Mol Biol. 2014;426:630-44 pubmed publisherShiokawa M, Kodama Y, Sekiguchi K, Kuwada T, Tomono T, Kuriyama K, et al. Laminin 511 is a target antigen in autoimmune pancreatitis. Sci Transl Med. 2018;10: pubmed publisherHettmann T, Gillies S, Kleinschmidt M, Piechotta A, Makioka K, Lemere C, et al. Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer\'s disease with reduced complement activation. Sci Rep. 2020;10:3294 pubmed publisherKruglova N, Meshkova T, Kopylov A, Mazurov D, Filatov A. Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP). PLoS ONE. 2017;12:e0182468 pubmed publisherHan L, Hu J, Ma B, Wen D, Zhang T, Lu Z, et al. IL-17A increases MHC class I expression and promotes T cell activation in papillary thyroid cancer patients with coexistent Hashimoto\'s thyroiditis. Diagn Pathol. 2019;14:52 pubmed publisherSato Y, Bolzenius J, Eteleeb A, Su X, Maher C, Sehn J, et al. CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blockade. JCI Insight. 2018;3: pubmed publisherRuscetti M, Leibold J, Bott M, Fennell M, Kulick A, Salgado N, et al. NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 2018;362:1416-1422 pubmed publisherDomae E, Hirai Y, Ikeo T, Goda S, Shimizu Y. Cytokine-mediated activation of human ex vivo-expanded V?9V?2 T cells. Oncotarget. 2017;8:45928-45942 pubmed publisherFischer M, Bantug G, Dimeloe S, Gubser P, Burgener A, Grählert J, et al. Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesis. Eur J Immunol. 2018;48:1632-1643 pubmed publisherStorm R, Persson B, Skalman L, Frängsmyr L, Lindström M, Rankin G, et al. Human Adenovirus Type 37 Uses αVβ1 and α3β1 Integrins for Infection of Human Corneal Cells. J Virol. 2017;91: pubmed publisherGopal S, Veracini L, Grall D, Butori C, Schaub S, Audebert S, et al. Fibronectin-guided migration of carcinoma collectives. Nat Commun. 2017;8:14105 pubmed publisherPascual G, Avgustinova A, Mejetta S, Martin M, Castellanos A, Attolini C, et al. Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature. 2017;541:41-45 pubmed publisherAlva Murillo N, Ochoa Zarzosa A, López Meza J. Sodium Octanoate Modulates the Innate Immune Response of Bovine Mammary Epithelial Cells through the TLR2/P38/JNK/ERK1/2 Pathway: Implications during Staphylococcus aureus Internalization. Front Cell Infect Microbiol. 2017;7:78 pubmed publisherLi Z, Liu Y, Liu X, Xue Y, Wang P, Liu L. Low-dose endothelial monocyte-activating polypeptide-II increases permeability of blood-tumor barrier via a PKC-ζ/PP2A-dependent signaling mechanism. Exp Cell Res. 2015;331:257-66 pubmed publisherSuzuki Y, Nagai N, Yamakawa K, Muranaka Y, Hokamura K, Umemura K. Recombinant tissue-type plasminogen activator transiently enhances blood-brain barrier permeability during cerebral ischemia through vascular endothelial growth factor-mediated endothelial endocytosis in mice. J Cereb Blood Flow Metab. 2015;35:2021-31 pubmed publisherNassa G, Salvati A, Tarallo R, Gigantino V, Alexandrova E, Memoli D, et al. Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells. Sci Adv. 2019;5:eaav5590 pubmed publisherLee T, David H, ENGSTROM A, CARPENTER B, KATZ D. Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans. elife. 2019;8: pubmed publisherCarofino B, Ayanga B, Tracey L, Brooke Bisschop T, Justice M. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016;5:645-53 pubmed publisherFerrán B, Martí Pàmies I, Alonso J, Rodríguez Calvo R, Aguiló S, Vidal F, et al. The nuclear receptor NOR-1 regulates the small muscle protein, X-linked (SMPX) and myotube differentiation. Sci Rep. 2016;6:25944 pubmed publisherAlfano L, Costa C, Caporaso A, Antonini D, Giordano A, Pentimalli F. HUR protects NONO from degradation by mir320, which is induced by p53 upon UV irradiation. Oncotarget. 2016;7:78127-78139 pubmed publisherChao T, Zhou X, Cao B, Liao P, Liu H, Chen Y, et al. Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53. Nat Commun. 2016;7:13755 pubmed publisherXiang L, Gilkes D, Hu H, Luo W, Bullen J, Liang H, et al. HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 2015;6:11768-78 pubmedLuo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza G. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. 2016;7:6379-97 pubmed publisherGarcia Cuellar M, Büttner C, Bartenhagen C, Dugas M, Slany R. Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes. Cell Rep. 2016;15:310-22 pubmed publisherLiu Z, Mar K, Hanners N, Perelman S, Kanchwala M, Xing C, et al. A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB. Nature. 2019;: pubmed publisherBailus B, Pyles B, McAlister M, O Geen H, Lockwood S, Adams A, et al. Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain. Mol Ther. 2016;24:548-55 pubmed publisherDas S, Ooi F, Cruz Corchado J, Fuller L, Weiner J, Prahlad V. Serotonin signaling by maternal neurons upon stress ensures progeny survival. elife. 2020;9: pubmed publisherSlaats G, Saldivar J, Bacal J, Zeman M, Kile A, Hynes A, et al. DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome. J Clin Invest. 2015;125:3657-66 pubmed publisherHsiao S, Chen M, Chen C, Chien M, Hua K, Hsiao M, et al. The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer. Ann Surg Oncol. 2015;22 Suppl 3:S1556-65 pubmed publisherAuclair G, Borgel J, Sanz L, Vallet J, Guibert S, Dumas M, et al. EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos. Genome Res. 2016;26:192-202 pubmed publisherYu R, Wang X, Moazed D. Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation. Nature. 2018;558:615-619 pubmed publisherShipkovenska G, Durango A, Kalocsay M, Gygi S, Moazed D. A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin. elife. 2020;9: pubmed publisherWan L, Chong S, Xuan F, Liang A, Cui X, Gates L, et al. Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature. 2020;577:121-126 pubmed publisherLamaa A, Humbert J, Aguirrebengoa M, Cheng X, Nicolas E, Cote J, et al. Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation. elife. 2020;9: pubmed publisherMannini L, C Lamaze F, Cucco F, Amato C, Quarantotti V, Rizzo I, et al. Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome. Sci Rep. 2015;5:16803 pubmed publisherRialdi A, Campisi L, Zhao N, Lagda A, Pietzsch C, Ho J, et al. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science. 2016;352:aad7993 pubmed publisherSutani T, Sakata T, Nakato R, Masuda K, Ishibashi M, Yamashita D, et al. Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation. Nat Commun. 2015;6:7815 pubmed publisherPakchuen S, Ishibashi M, Takakusagi E, Shirahige K, Sutani T. Physical Association of Saccharomyces cerevisiae Polo-like Kinase Cdc5 with Chromosomal Cohesin Facilitates DNA Damage Response. J Biol Chem. 2016;291:17228-46 pubmed publisherWalerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, et al. Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer. Nat Cell Biol. 2016;18:897-909 pubmed publisherAdriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, et al. p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat Med. 2016;22:861-8 pubmed publisherCarroll R, Troelnikov A, Chong A. Virtual Global Transplant Laboratory Standard Operating Protocol for Donor Alloantigen-specific Interferon-gamma ELISPOT Assay. Transplant Direct. 2016;2:e111 pubmedMufarrege E, Giorgetti S, Etcheverrigaray M, Terry F, Martin W, De Groot A. De-immunized and Functional Therapeutic (DeFT) versions of a long lasting recombinant alpha interferon for antiviral therapy. Clin Immunol. 2017;176:31-41 pubmed publisherMiners J, Palmer J, Love S. Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer\'s Disease. Brain Pathol. 2016;26:533-41 pubmed publisherCasali B, Reed Geaghan E, Landreth G. Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer\'s disease. J Neuroinflammation. 2018;15:43 pubmed publisherStevanović S, Pasetto A, Helman S, Gartner J, Prickett T, Howie B, et al. Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer. Science. 2017;356:200-205 pubmed publisherOtt P, Hu Z, Keskin D, Shukla S, Sun J, Bozym D, et al. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017;547:217-221 pubmed publisherHe X, Su F, Taccone F, Laporte R, Kjølbye A, Zhang J, et al. A Selective V(1A) Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock. Crit Care Med. 2016;44:23-31 pubmed publisherLiu H, Garzoni L, Herry C, Durosier L, Cao M, Burns P, et al. Can Monitoring Fetal Intestinal Inflammation Using Heart Rate Variability Analysis Signal Incipient Necrotizing Enterocolitis of the Neonate?. Pediatr Crit Care Med. 2016;17:e165-76 pubmed publisherSingal S, Biradar A, Mulchandani A, Rajesh -. Ultrasensitive electrochemical immunosensor based on Pt nanoparticle-graphene composite. Appl Biochem Biotechnol. 2014;174:971-83 pubmed publisherBrindle E, Stevens D, Crudder C, Levin C, Garrett D, Lyman C, et al. A multiplex immunoassay method for simultaneous quantification of iron, vitamin A and inflammation status markers. PLoS ONE. 2014;9:e115164 pubmed publisherWilliams R, Bate C. An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling. Neuropharmacology. 2016;101:566-75 pubmed publisherOsborne C, West E, Nolan W, McHale Owen H, Williams A, Bate C. Glimepiride protects neurons against amyloid-β-induced synapse damage. Neuropharmacology. 2016;101:225-36 pubmed publisherAhmed S, Hossain M, Park J, Kim S, Lee D, Suzuki T, et al. Metal enhanced fluorescence on nanoporous gold leaf-based assay platform for virus detection. Biosens Bioelectron. 2014;58:33-9 pubmed publisherGoncharova E, Kostyro Y, Ivanov A, Zenkova M. A Novel Sulfonated Derivative of β-Cyclodextrin Effectively Inhibits Influenza A Virus Infection in vitro and in vivo. Acta Naturae. 2019;11:20-30 pubmed publisherSinthujaroen P, Wanachottrakul N, Pinkaew D, Petersen J, Phongdara A, Sheffield Moore M, et al. Elevation of serum fortilin levels is specific for apoptosis and signifies cell death in vivo. BBA Clin. 2014;2:103-111 pubmedAndo T, Kashiwakura J, Itoh Nagato N, Yamashita H, Baba M, Kawakami Y, et al. Histamine-releasing factor enhances food allergy. J Clin Invest. 2017;127:4541-4553 pubmed publisherRamm R, Hartmann T, Tudorache I, Haverich A, Hilfiker A. No evidence for αGal epitope transfer from media containing FCS onto human endothelial cells in culture. Xenotransplantation. 2015;22:345-55 pubmed publisherLu Y, Shao A, Shan Y, Zhao H, Leiguo M, Zhang Y, et al. A standardized quantitative method for detecting remnant alpha-Gal antigen in animal tissues or animal tissue-derived biomaterials and its application. Sci Rep. 2018;8:15424 pubmed publisherMantile F, Trovato M, Santoni A, Barba P, Ottonello S, De Berardinis P, et al. Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-A? antibodies induced by multimeric protein antigen (1-11)E2, preserving the Igg1-skewed isotype distribution. PLoS ONE. 2014;9:e101474 pubmed publisherde la Escosura Muñiz A, Plichta Z, Horák D, Merkoçi A. Alzheimer\'s disease biomarkers detection in human samples by efficient capturing through porous magnetic microspheres and labelling with electrocatalytic gold nanoparticles. Biosens Bioelectron. 2015;67:162-9 pubmed publisherThompson A, Kanamarlapudi V. Distinct regions in the C-Terminus required for GLP-1R cell surface expression, activity and internalisation. Mol Cell Endocrinol. 2015;413:66-77 pubmed publisherThompson A, Stephens J, Bain S, Kanamarlapudi V. Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation. PLoS ONE. 2016;11:e0154229 pubmed publisherXing L, Xu Y, Sun K, Wang H, Zhang F, Zhou Z, et al. Identification of a peptide for folate receptor alpha by phage display and its tumor targeting activity in ovary cancer xenograft. Sci Rep. 2018;8:8426 pubmed publisherCho S, Kil E, Cho S, Byun H, Kang E, Choi H, et al. Development of novel detection system for sweet potato leaf curl virus using recombinant scFv. Sci Rep. 2020;10:8039 pubmed publisherDuval N, Daubas P, Bourcier de Carbon C, St Cloment C, Tinevez J, Lopes M, et al. Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord. Development. 2014;141:1726-36 pubmed publisherPuthia M, Ambite I, Cafaro C, Butler D, Huang Y, Lutay N, et al. IRF7 inhibition prevents destructive innate immunity-A target for nonantibiotic therapy of bacterial infections. Sci Transl Med. 2016;8:336ra59 pubmed publisherRackov G, Hernandez Jimenez E, Shokri R, Carmona Rodríguez L, Manes S, Alvarez Mon M, et al. p21 mediates macrophage reprogramming through regulation of p50-p50 NF-?B and IFN-?. J Clin Invest. 2016;126:3089-103 pubmed publisherKumar A, Chamoto K, Chowdhury P, Honjo T. Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy. elife. 2020;9: pubmed publisherWuggenig P, Kaya B, Melhem H, Ayata C, Hruz P, Sayan A, et al. Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice. Commun Biol. 2020;3:130 pubmed publisherKawalkowska J, Ogbechi J, Venables P, Williams R. cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs. Sci Adv. 2019;5:eaaw5422 pubmed publisherLeone R, Zhao L, Englert J, Sun I, Oh M, Sun I, et al. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science. 2019;366:1013-1021 pubmed publisherVazquez Iglesias L, Barcia Castro L, Rodríguez Quiroga M, Páez de la Cadena M, Rodríguez Berrocal J, Cordero O. Surface expression marker profile in colon cancer cell lines and sphere-derived cells suggests complexity in CD26+ cancer stem cells subsets. Biol Open. 2019;8: pubmed publisherKatsuda T, Matsuzaki J, Yamaguchi T, Yamada Y, Prieto Vila M, Hosaka K, et al. Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes. elife. 2019;8: pubmed publisherXue Y, Liao B, Xie Y, Li S, Ma X, Sun X. Establishment of an ectodermal dysplasia related gene EDA Knockout human embryonic stem cell line (WAe001-A-22) by CRISPR-Cas9 technology. Stem Cell Res. 2019;34:101379 pubmed publisherYap L, Wang J, Moreno Moral A, Chong L, Sun Y, Harmston N, et al. In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors. Cell Rep. 2019;26:3231-3245.e9 pubmed publisherJuno J, Stalker A, Waruk J, Oyugi J, Kimani M, Plummer F, et al. Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment. Retrovirology. 2015;12:17 pubmed publisherBoer M, Prins C, van Meijgaarden K, van Dissel J, Ottenhoff T, Joosten S. Mycobacterium bovis BCG Vaccination Induces Divergent Proinflammatory or Regulatory T Cell Responses in Adults. Clin Vaccine Immunol. 2015;22:778-88 pubmed publisherBogachek M, Park J, De Andrade J, Lorenzen A, Kulak M, White J, et al. Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas. Stem Cell Reports. 2016;7:1140-1151 pubmed publisherChen Y, Qin X, An Q, Yi J, Feng F, Yin D, et al. Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes. EBioMedicine. 2018;32:31-42 pubmed publisherJia D, Duan F, Peng P, Sun L, Ruan Y, Gu J. Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice. PLoS ONE. 2015;10:e0121939 pubmed publisherDoni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, et al. An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. J Exp Med. 2015;212:905-25 pubmed publisherJang K, Mano H, Aoki K, Hayashi T, Muto A, Nambu Y, et al. Mitochondrial function provides instructive signals for activation-induced B-cell fates. Nat Commun. 2015;6:6750 pubmed publisherYe Y, Liu M, Tang L, Du F, Liu Y, Hao P, et al. Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC/EGR1 axis. Arthritis Res Ther. 2019;21:92 pubmed publisherMaillet A, TAN K, Chai X, Sadananda S, Mehta A, Ooi J, et al. Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes. Sci Rep. 2016;6:25333 pubmed publisherKudová J, Prochazkova J, Vašíček O, Perecko T, Sedláčková M, Pesl M, et al. HIF-1alpha Deficiency Attenuates the Cardiomyogenesis of Mouse Embryonic Stem Cells. PLoS ONE. 2016;11:e0158358 pubmed publisherSchaut R, Grinnage Pulley T, Esch K, Toepp A, Duthie M, Howard R, et al. Recovery of antigen-specific T cell responses from dogs infected with Leishmania (L.) infantum by use of vaccine associated TLR-agonist adjuvant. Vaccine. 2016;34:5225-5234 pubmed publisherMcGill J, Wang Y, Ganta C, Boorgula G, Ganta R. Antigen-Specific CD4+CD8+ Double-Positive T Cells Are Increased in the Blood and Spleen During Ehrlichia chaffeensis Infection in the Canine Host. Front Immunol. 2018;9:1585 pubmed publisherSchuetz C, Lee K, Scott R, Kojima L, Washburn L, Liu L, et al. Regulatory B Cell-Dependent Islet Transplant Tolerance Is Also Natural Killer Cell Dependent. Am J Transplant. 2017;17:1656-1662 pubmed publisherHurst J, Hoffmann M, Pace M, Williams J, Thornhill J, Hamlyn E, et al. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption. Nat Commun. 2015;6:8495 pubmed publisherHoffmann M, Pantazis N, Martin G, Hickling S, Hurst J, Meyerowitz J, et al. Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection. PLoS Pathog. 2016;12:e1005661 pubmed publisherNeumann B, Shi T, Gan L, Klippert A, Daskalaki M, Stolte Leeb N, et al. Comprehensive panel of cross-reacting monoclonal antibodies for analysis of different immune cells and their distribution in the common marmoset (Callithrix jacchus). J Med Primatol. 2016;45:139-46 pubmed publisherMiles B, Miller S, Folkvord J, Levy D, Rakasz E, Skinner P, et al. Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection. PLoS Pathog. 2016;12:e1005924 pubmed publisherChao T, Chang M, Su S, Su S. Inducible nitric oxide synthase mediates MG132 lethality in leukemic cells through mitochondrial depolarization. Free Radic Biol Med. 2014;74:175-87 pubmed publisherAmpem G, Azegrouz H, Bacsadi Ã, Balogh L, Schmidt S, Thuróczy J, et al. Adipose tissue macrophages in non-rodent mammals: a comparative study. Cell Tissue Res. 2016;363:461-78 pubmed publisherMannhardt I, Breckwoldt K, Letuffe Brenière D, Schaaf S, Schulz H, Neuber C, et al. Human Engineered Heart Tissue: Analysis of Contractile Force. Stem Cell Reports. 2016;7:29-42 pubmed publisherGuo C, Ma X, Xing Y, Zheng C, Xu Y, Shan L, et al. Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells. Cell. 2020;181:621-636.e22 pubmed publisherHu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, et al. ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Nucleic Acids Res. 2020;48:6001-6018 pubmed publisherTorres Mejía E, Trumbach D, Kleeberger C, Dornseifer U, Orschmann T, Bäcker T, et al. Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis. Sci Rep. 2020;10:1984 pubmed publisherEscande Beillard N, Loh A, Saleem S, Kanata K, Hashimoto Y, Altunoglu U, et al. Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2. Neuron. 2020;107:82-94.e6 pubmed publisherLee C, Aizawa K, Jiang J, Kung S, Jain R. JLP-centrosome is essential for the microtubule-mediated nucleocytoplasmic transport induced by extracellular stimuli. Sci Adv. 2019;5:eaav0318 pubmed publisherChong W, Wang W, Lo C, Chiu T, Chang T, Liu Y, et al. Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages. elife. 2020;9: pubmed publisherLi Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, et al. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest. 2019;129:1129-1151 pubmed publisherBendriem R, Singh S, Aleem A, Antonetti D, Ross M. Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex. elife. 2019;8: pubmed publisherJansch C, Günther K, Waider J, Ziegler G, Forero A, Kollert S, et al. Generation of a human induced pluripotent stem cell (iPSC) line from a 51-year-old female with attention-deficit/hyperactivity disorder (ADHD) carrying a duplication of SLC2A3. Stem Cell Res. 2018;28:136-140 pubmed publisherGao Q, Yang Z, Xu S, Li X, Yang X, Jin P, et al. Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer. J Exp Med. 2019;216:688-703 pubmed publisherLee J, Termglinchan V, Diecke S, Itzhaki I, Lam C, Garg P, et al. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. 2019;572:335-340 pubmed publisherFarhy C, Hariharan S, Ylanko J, Orozco L, Zeng F, Pass I, et al. Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape. elife. 2019;8: pubmed publisherGümürdü A, Yildiz R, Eren E, Karakülah G, Unver T, Genc S, et al. MicroRNA exocytosis by large dense-core vesicle fusion. Sci Rep. 2017;7:45661 pubmed publisherSun J, Carlson Stevermer J, Das U, Shen M, Delenclos M, Snead A, et al. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019;10:53 pubmed publisherPaul A, Wang B. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. Mol Cell. 2017;66:458-472.e5 pubmed publisherRai A, Chen J, Selbach M, Pelkmans L. Kinase-controlled phase transition of membraneless organelles in mitosis. Nature. 2018;559:211-216 pubmed publisherKizuka Y, Nakano M, Kitazume S, Saito T, Saido T, Taniguchi N. Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem J. 2016;473:21-30 pubmed publisherWang Y, Wu Q, Yang P, Wang C, Liu J, Ding W, et al. LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun. 2016;7:10481 pubmed publisherSchokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed publisherYu Z, Mouillesseaux K, Kushner E, Bautch V. Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication. PLoS ONE. 2016;11:e0168334 pubmed publisherSmith M, Harley M, Kemp A, Wills J, Lee M, Arends M, et al. CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Dev Cell. 2018;44:217-232.e11 pubmed publisherFletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh J, et al. The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. EMBO J. 2018;37: pubmed publisherHuang N, Zhang D, Li F, Chai P, Wang S, Teng J, et al. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Nat Commun. 2018;9:4511 pubmed publisherBaudoin N, Nicholson J, Soto K, Martin O, Chen J, Cimini D. Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells. elife. 2020;9: pubmed publisherDel Rosario B, Kriz A, Del Rosario A, Anselmo A, Fry C, White F, et al. Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition. elife. 2019;8: pubmed publisherHollingworth R, Skalka G, Stewart G, Hislop A, Blackbourn D, Grand R. Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. Viruses. 2015;7:2908-27 pubmed publisherRenaud E, Barascu A, Rosselli F. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res. 2016;44:648-56 pubmed publisherTamrakar P, Shrestha P, Briski K. Dorsomedial hindbrain catecholamine regulation of hypothalamic astrocyte glycogen metabolic enzyme protein expression: Impact of estradiol. Neuroscience. 2015;292:34-45 pubmed publisherNandi S, Zheng H, Sharma N, Shahshahan H, Patel K, Mishra P. Lack of miR-133a Decreases Contractility of Diabetic Hearts: A Role for Novel Cross Talk Between Tyrosine Aminotransferase and Tyrosine Hydroxylase. Diabetes. 2016;65:3075-90 pubmed publisherSun H, Zhang M, Cheng K, Li P, Han S, Li R, et al. Resistance of glioma cells to nutrient-deprived microenvironment can be enhanced by CD133-mediated autophagy. Oncotarget. 2016;7:76238-76249 pubmed publisherOng D, Hu B, Ho Y, Sauvé C, Bristow C, Wang Q, et al. PAF promotes stemness and radioresistance of glioma stem cells. Proc Natl Acad Sci U S A. 2017;114:E9086-E9095 pubmed publisherQi Y, Qiu Q, Gu X, Tian Y, Zhang Y. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. Sci Rep. 2016;6:24700 pubmed publisherBakr A, Köcher S, Volquardsen J, Petersen C, Borgmann K, Dikomey E, et al. Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1. Oncotarget. 2016;7:57679-57693 pubmed publisherSettembre C, Medina D. TFEB and the CLEAR network. Methods Cell Biol. 2015;126:45-62 pubmed publisherBartolomeo R, Cinque L, De Leonibus C, Forrester A, Salzano A, Monfregola J, et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 2017;127:3717-3729 pubmed publisherLi Y, Hu H, Butterworth M, Tian J, Zhu M, O Neil R. Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney. PLoS ONE. 2016;11:e0155006 pubmed publisherChimote A, Gawali V, Newton H, Wise Draper T, Conforti L. A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer. Front Pharmacol. 2020;11:143 pubmed publisherZouk H, d Hennezel E, Du X, Ounissi Benkalha H, Piccirillo C, Polychronakos C. Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus. Clin Exp Immunol. 2014;175:485-97 pubmed publisherWike C, Graves H, Hawkins R, Gibson M, Ferdinand M, Zhang T, et al. Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis. elife. 2016;5:e11402 pubmed publisherHiasa M, Togawa N, Miyaji T, Omote H, Yamamoto A, Moriyama Y. Essential role of vesicular nucleotide transporter in vesicular storage and release of nucleotides in platelets. Physiol Rep. 2014;2: pubmed publisherHarada Y, Hiasa M. Immunological identification of vesicular nucleotide transporter in intestinal L cells. Biol Pharm Bull. 2014;37:1090-5 pubmedYilmazer Hanke D, Mayer T, Müller H, Neugebauer H, Abaei A, Scheuerle A, et al. Histological correlates of postmortem ultra-high-resolution single-section MRI in cortical cerebral microinfarcts. Acta Neuropathol Commun. 2020;8:33 pubmed publisherMa X, Zhu Y, Lu J, Xie J, Li C, Shin W, et al. Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau. elife. 2020;9: pubmed publisherKjell J, Gotz M. Filling the Gaps - A Call for Comprehensive Analysis of Extracellular Matrix of the Glial Scar in Region- and Injury-Specific Contexts. Front Cell Neurosci. 2020;14:32 pubmed publisherShi Z, Pelletier N, Wong J, Li B, Sdrulla A, Madden C, et al. Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus. elife. 2020;9: pubmed publisherFan D, Chettouh Z, Consalez G, Brunet J. Taste bud formation depends on taste nerves. elife. 2019;8: pubmed publisherLi C, Li X, Bi Z, Sugino K, Wang G, Zhu T, et al. Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages. elife. 2020;9: pubmed publisherElvira R, Cha S, Noh G, Kim K, Han J. PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila. Int J Mol Sci. 2020;21: pubmed publisherStrausfeld N, Wolff G, Sayre M. Mushroom body evolution demonstrates homology and divergence across Pancrustacea. elife. 2020;9: pubmed publisherOtto T, Candido S, Pilarz M, Sicinska E, Bronson R, Bowden M, et al. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017;114:10660-10665 pubmed publisherLi C, Chen W, Wang J, Xia M, Jia Z, Guo C, et al. Nicotinamide riboside rescues angiotensin II-induced cerebral small vessel disease in mice. CNS Neurosci Ther. 2020;26:438-447 pubmed publisherJörns A, Ishikawa D, Teraoku H, Yoshimoto T, Wedekind D, Lenzen S. Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes. BMC Med. 2020;18:33 pubmed publisherAaltonen N, Singha P, Jakupović H, Wirth T, Samaranayake H, Pasonen Seppänen S, et al. High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils. Biol Proced Online. 2020;22:6 pubmed publisherMatsumura K, Seiriki K, Okada S, Nagase M, Ayabe S, Yamada I, et al. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. Nat Commun. 2020;11:859 pubmed publisherGuven A, Kalebic N, Long K, Florio M, Vaid S, Brandl H, et al. Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex. elife. 2020;9: pubmed publisherWilliams P, Harder J, Foxworth N, Cochran K, Philip V, Porciatti V, et al. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science. 2017;355:756-760 pubmed publisherWendeln A, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 2018;556:332-338 pubmed publisherPan H, Fatima M, Li A, Lee H, Cai W, Horwitz L, et al. Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch. Neuron. 2019;103:1135-1149.e6 pubmed publisherGranger A, Wang W, Robertson K, El Rifai M, Zanello A, Bistrong K, et al. Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner. elife. 2020;9: pubmed publisherRubio Fernández M, Uribe M, Vicente Tejedor J, Germain F, Susín Lara C, Quereda C, et al. Impairment of photoreceptor ribbon synapses in a novel Pomt1 conditional knockout mouse model of dystroglycanopathy. Sci Rep. 2018;8:8543 pubmed publisherBanerjee A, Lee J, Nemcova P, Liu C, Kaeser P. Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release. elife. 2020;9: pubmed publisherHacisalihoglu P, Kucukodaci Z, Gundogdu G, Bilgic B. The Correlation Between 1p/19q Codeletion, IDH1 Mutation, p53 Overexpression and Their Prognostic Roles in 41 Turkish Anaplastic Oligodendroglioma Patients. Turk Neurosurg. 2017;27:682-689 pubmed publisherRonellenfitsch M, Oh J, Satomi K, Sumi K, Harter P, Steinbach J, et al. CASP9 germline mutation in a family with multiple brain tumors. Brain Pathol. 2018;28:94-102 pubmed publisherJin J, Ravindran P, Di Meo D, Püschel A. Igf1R/InsR function is required for axon extension and corpus callosum formation. PLoS ONE. 2019;14:e0219362 pubmed publisherOno K, Keller J, López Ramírez O, González Garrido A, Zobeiri O, Chang H, et al. Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations. Nat Commun. 2020;11:63 pubmed publisherOrbán Kis K, Szabadi T, Szilágyi T. The loss of Ivy cells and the hippocampal input modulatory O-LM cells contribute to the emergence of hyperexcitability in the hippocampus. Rom J Morphol Embryol. 2015;56:155-61 pubmedZhang L, Hernandez V, Vázquez Juárez E, Chay F, Barrio R. Thirst Is Associated with Suppression of Habenula Output and Active Stress Coping: Is there a Role for a Non-canonical Vasopressin-Glutamate Pathway?. Front Neural Circuits. 2016;10:13 pubmed publisherTaube J, Young G, McMiller T, Chen S, Salas J, Pritchard T, et al. Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade. Clin Cancer Res. 2015;21:3969-76 pubmed publisherChen P, Roh W, Reuben A, Cooper Z, Spencer C, Prieto P, et al. Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade. Cancer Discov. 2016;6:827-37 pubmed publisherArnandis T, Ferrer Vicens I, Torres L, García C, García Trevijano E, Zaragoza R, et al. Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution. Biochem J. 2014;459:355-68 pubmed publisherKuhn T, Pascual García P, Gozalo A, Little S, Capelson M. Chromatin targeting of nuclear pore proteins induces chromatin decondensation. J Cell Biol. 2019;218:2945-2961 pubmed publisherChen H, Wei Z, Sun J, Bhattacharya A, Savage D, Serda R, et al. A recellularized human colon model identifies cancer driver genes. Nat Biotechnol. 2016;34:845-51 pubmed publisherWedekind M, Haworth K, Arnold M, Stanek J, Lee D, Cripe T. Immune profiles of desmoplastic small round cell tumor and synovial sarcoma suggest different immunotherapeutic susceptibility upfront compared to relapse specimens. Pediatr Blood Cancer. 2018;65:e27313 pubmed publisherLiu Z, Wen J, Wu C, Hu C, Wang J, Bao Q, et al. MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma. Aging (Albany NY). 2020;12:1213-1236 pubmed publisherZhao J, Li G, Zhao X, Lin X, Gao Y, Raimundo N, et al. Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss. Aging (Albany NY). 2020;12:5590-5611 pubmed publisherGao J, Wu Y, He D, Zhu X, Li H, Liu H, et al. Anti-aging effects of Ribes meyeri anthocyanins on neural stem cells and aging mice. Aging (Albany NY). 2020;12:17738-17753 pubmed publisherSterpka A, Yang J, Strobel M, Zhou Y, Pauplis C, Chen X. Diverged morphology changes of astrocytic and neuronal primary cilia under reactive insults. Mol Brain. 2020;13:28 pubmed publisherYoshino M, Saito K, Kawasaki K, Horiike T, Shinmyo Y, Kawasaki H. The origin and development of subcortical U-fibers in gyrencephalic ferrets. Mol Brain. 2020;13:37 pubmed publisherBhattarai P, Cosacak M, Mashkaryan V, Demir S, Popova S, Govindarajan N, et al. Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer\'s model of adult zebrafish brain. PLoS Biol. 2020;18:e3000585 pubmed publisherLange C, Rost F, Machate A, Reinhardt S, Lesche M, Weber A, et al. Single cell sequencing of radial glia progeny reveals the diversity of newborn neurons in the adult zebrafish brain. Development. 2020;147: pubmed publisherLaukoter S, Beattie R, Pauler F, Amberg N, Nakayama K, Hippenmeyer S. Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development. Nat Commun. 2020;11:195 pubmed publisherTrevino A, Sinnott Armstrong N, Andersen J, Yoon S, Huber N, Pritchard J, et al. Chromatin accessibility dynamics in a model of human forebrain development. Science. 2020;367: pubmed publisherLohman R, Hamidon J, Reid R, Rowley J, Yau M, Halili M, et al. Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nat Commun. 2017;8:351 pubmed publisherNomura Komoike K, Saitoh F, Fujieda H. Phosphatidylserine recognition and Rac1 activation are required for Müller glia proliferation, gliosis and phagocytosis after retinal injury. Sci Rep. 2020;10:1488 pubmed publisherSzonyi A, Sos K, Nyilas R, Schlingloff D, Domonkos A, Takács V, et al. Brainstem nucleus incertus controls contextual memory formation. Science. 2019;364: pubmed publisherDiniz G, Battagello D, Cherubini P, Reyes Mendoza J, Luna Illades C, Klein M, et al. Melanin-concentrating hormone peptidergic system: Comparative morphology between muroid species. J Comp Neurol. 2019;527:2973-3001 pubmed publisherYu K, Lin C, Hatcher A, Lozzi B, Kong K, Huang Hobbs E, et al. PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature. 2020;578:166-171 pubmed publisherLorenzo L, Godin A, Ferrini F, Bachand K, Plasencia Fernandez I, Labrecque S, et al. Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain. Nat Commun. 2020;11:869 pubmed publisherLuke M, LeVatte T, Rutishauser U, Tremblay F, Clarke D. Polysialylated Neural Cell Adhesion Molecule Protects Against Light-Induced Retinal Degeneration. Invest Ophthalmol Vis Sci. 2016;57:5066-5075 pubmed publisherNakamoto C, Konno K, Miyazaki T, Nakatsukasa E, Natsume R, Abe M, et al. Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain. J Comp Neurol. 2019;: pubmed publisherKuo B, Baldwin E, Layman W, Taketo M, Zuo J. In Vivo Cochlear Hair Cell Generation and Survival by Coactivation of β-Catenin and Atoh1. J Neurosci. 2015;35:10786-98 pubmed publisherShimada M, Dumitrache L, Russell H, McKinnon P. Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015;34:2465-80 pubmed publisherWu X, Wu X, Ma Y, Shao F, Tan Y, Tan T, et al. CUG-binding protein 1 regulates HSC activation and liver fibrogenesis. Nat Commun. 2016;7:13498 pubmed publisherSeike M, Omatsu Y, Watanabe H, Kondoh G, Nagasawa T. Stem cell niche-specific Ebf3 maintains the bone marrow cavity. Genes Dev. 2018;32:359-372 pubmed publisherSakano H, Zorio D, Wang X, Ting Y, Noble W, MacCoss M, et al. Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein. J Comp Neurol. 2017;525:3341-3359 pubmed publisherSousounis K, Bryant D, Martínez Fernández J, Eddy S, Tsai S, Gundberg G, et al. Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration. elife. 2020;9: pubmed publisherGarita Hernandez M, Routet F, Guibbal L, Khabou H, Toualbi L, Riancho L, et al. AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells. Int J Mol Sci. 2020;21: pubmed publisherVigouroux R, Cesar Q, Chedotal A, Nguyen Ba Charvet K. Revisiting the role of Dcc in visual system development with a novel eye clearing method. elife. 2020;9: pubmed publisherPeng Y, Yuan G, Khan S, Nanduri J, Makarenko V, Reddy V, et al. Regulation of hypoxia-inducible factor-? isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014;592:3841-58 pubmed publisherEspana Agusti J, Tuveson D, Adams D, Matakidou A. A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep. 2015;5:11061 pubmed publisherFu H, Rodriguez G, Herman M, Emrani S, Nahmani E, Barrett G, et al. Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer\'s Disease. Neuron. 2017;93:533-541.e5 pubmed publisherBraak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed publisherQian Q, Liu Q, Zhou D, Pan H, Liu Z, He F, et al. Brain-specific ablation of Efr3a promotes adult hippocampal neurogenesis via the brain-derived neurotrophic factor pathway. FASEB J. 2017;31:2104-2113 pubmed publisherDwyer C, Scudder S, Lin Y, Dozier L, Phan D, Allen N, et al. Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice. Sci Rep. 2017;7:46576 pubmed publisherBaglietto Vargas D, Prieto G, Limon A, Forner S, Rodriguez Ortiz C, Ikemura K, et al. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer\'s disease. Aging Cell. 2018;17:e12791 pubmed publisherBarros Viegas A, Carmona V, Ferreiro E, Guedes J, Cardoso A, Cunha P, et al. miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer\'s Disease. Mol Ther Nucleic Acids. 2020;19:1219-1236 pubmed publisherMorona R, Ferran J, Puelles L, González A. Gene expression analysis of developing cell groups in the pretectal region of Xenopus laevis. J Comp Neurol. 2017;525:715-752 pubmed publisherHan Y, Zhang Y, Kim H, Grayson V, Jovasevic V, Ren W, et al. Excitatory VTA to DH projections provide a valence signal to memory circuits. Nat Commun. 2020;11:1466 pubmed publisherJara J, Stanford M, Zhu Y, Tu M, Hauswirth W, Bohn M, et al. Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex. Gene Ther. 2016;23:272-82 pubmed publisherTosches M, Yamawaki T, Naumann R, Jacobi A, Tushev G, Laurent G. Evolution of pallium, hippocampus, and cortical cell types revealed by single-cell transcriptomics in reptiles. Science. 2018;360:881-888 pubmed publisherGouty Colomer L, Hosseini B, Marcelo I, Schreiber J, Slump D, Yamaguchi S, et al. Arc expression identifies the lateral amygdala fear memory trace. Mol Psychiatry. 2016;21:364-75 pubmed publisherRao Ruiz P, Couey J, Marcelo I, Bouwkamp C, Slump D, Matos M, et al. Engram-specific transcriptome profiling of contextual memory consolidation. Nat Commun. 2019;10:2232 pubmed publisherDuan W, Guo M, Yi L, Zhang J, Bi Y, Liu Y, et al. Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice. Aging (Albany NY). 2019;11:2457-2476 pubmed publisherCollins L, Brunjes P. The mouse olfactory peduncle 4: Development of synapses, perineuronal nets, and capillaries. J Comp Neurol. 2019;: pubmed publisherXiong X, Gu L, Wang Y, Luo Y, Zhang H, Lee J, et al. Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms. J Neuroinflammation. 2016;13:241 pubmed publisherZhang L, Pan J, Mamtilahun M, Zhu Y, Wang L, Venkatesh A, et al. Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion. Theranostics. 2020;10:74-90 pubmed publisherGremlich S, Roth Kleiner M, Equey L, Fytianos K, Schittny J, Cremona T. Tenascin-C inactivation impacts lung structure and function beyond lung development. Sci Rep. 2020;10:5118 pubmed publisherSomerville T, Biffi G, Da ler Plenker J, Hur S, He X, Vance K, et al. Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. elife. 2020;9: pubmed publisherSun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, et al. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer\'s disease. J Neuroinflammation. 2020;17:72 pubmed publisherHu S, Hu M, Liu J, Zhang B, Zhang Z, Zhou F, et al. Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson\'s Disease. Neuropsychiatr Dis Treat. 2020;16:651-663 pubmed publisherBell L, Lenhart A, Rosenwald A, Monoranu C, Berberich Siebelt F. Lymphoid Aggregates in the CNS of Progressive Multiple Sclerosis Patients Lack Regulatory T Cells. Front Immunol. 2019;10:3090 pubmed publisherKim M, Chung Y, Kim H, Woo J, Ahn S, Park S. Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast. Breast Cancer Res. 2020;22:32 pubmed publisherPridans C, Raper A, Davis G, Alves J, Sauter K, Lefèvre L, et al. Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus. J Immunol. 2018;201:2683-2699 pubmed publisherCarballo Carbajal I, Laguna A, Romero Gimenez J, Cuadros T, Bove J, Martinez Vicente M, et al. Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson\'s disease pathogenesis. Nat Commun. 2019;10:973 pubmed publisherLi W, Chen C, Zhao X, Ye H, Zhao Y, Fu Z, et al. HIF-2? regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma. J Cell Mol Med. 2017;21:2896-2908 pubmed publisherWang Y, Zhang X, Hua Z, Xie L, Jiang X, Wang R, et al. Blood Oxygen Level-Dependent Imaging and Intravoxel Incoherent Motion MRI of Early Contrast-Induced Acute Kidney Injury in a Rabbit Model. Kidney Blood Press Res. 2019;44:496-512 pubmed publisherFamulari E, Navarro Tableros V, Herrera Sanchez M, Bortolussi G, Gai M, Conti L, et al. Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice. Sci Rep. 2020;10:887 pubmed publisherZhang Y, Mao X, Chen W, Guo X, Yu L, Jiang F, et al. A Discovery of Clinically Approved Formula FBRP for Repositioning to Treat HCC by Inhibiting PI3K/AKT/NF-κB Activation. Mol Ther Nucleic Acids. 2020;19:890-904 pubmed publisherKazuki Y, Gao F, Li Y, Moyer A, Devenney B, Hiramatsu K, et al. A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21. elife. 2020;9: pubmed publisherLackie R, Marques Lopes J, Ostapchenko V, Good S, Choy W, van Oosten Hawle P, et al. Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer\'s disease. Acta Neuropathol Commun. 2020;8:143 pubmed publisherHan Y, Wang W, Yang Y, Sun Y, Xiao G, Tian Q, et al. Amide Proton Transfer Imaging in Predicting Isocitrate Dehydrogenase 1 Mutation Status of Grade II/III Gliomas Based on Support Vector Machine. Front Neurosci. 2020;14:144 pubmed publisherGihr G, Horvath Rizea D, Hekeler E, Ganslandt O, Henkes H, Hoffmann K, et al. Histogram Analysis of Diffusion Weighted Imaging in Low-Grade Gliomas: in vivo Characterization of Tumor Architecture and Corresponding Neuropathology. Front Oncol. 2020;10:206 pubmed publisherVance M, Llanga T, Bennett W, Woodard K, Murlidharan G, Chungfat N, et al. AAV Gene Therapy for MPS1-associated Corneal Blindness. Sci Rep. 2016;6:22131 pubmed publisherSu S, Chen J, Yao H, Liu J, Yu S, Lao L, et al. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. Cell. 2018;172:841-856.e16 pubmed publisherZeng L, Wang B, Merillat S, Minakawa E, Perkins M, Ramani B, et al. Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3. Neurobiol Dis. 2015;82:281-288 pubmed publisherIto M, Nakamura K, Mori F, Miki Y, Tanji K, Wakabayashi K. Novel eosinophilic neuronal cytoplasmic inclusions in the external cuneate nucleus of humans. Neuropathology. 2016;36:441-447 pubmed publisherKobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisherWalker W, Oehler A, Edinger A, Wagner K, Gunn T. Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy. Biol Cell. 2016;108:324-337 pubmed publisherRussell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld F, et al. Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition. Nat Commun. 2015;6:7677 pubmed publisherSipos F, Constantinovits M, Valcz G, Tulassay Z, Műzes G. Association of hepatocyte-derived growth factor receptor/caudal type homeobox 2 co-expression with mucosal regeneration in active ulcerative colitis. World J Gastroenterol. 2015;21:8569-79 pubmed publisherBorghesan M, Fusilli C, Rappa F, Panebianco C, Rizzo G, Oben J, et al. DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression. Cancer Res. 2016;76:594-606 pubmed publisherPan H, Jiang N, Sun S, Jiang H, Xu J, Jiang X, et al. UHRF1-repressed 5\'-hydroxymethylcytosine is essential for the male meiotic prophase I. Cell Death Dis. 2020;11:142 pubmed publisherBoj M, Chauvigné F, Zapater C, Cerdà J. Gonadotropin-Activated Androgen-Dependent and Independent Pathways Regulate Aquaporin Expression during Teleost (Sparus aurata) Spermatogenesis. PLoS ONE. 2015;10:e0142512 pubmed publisherChauvigné F, Ollé J, Gonzalez W, Duncan N, Gimenez I, Cerdà J. Toward developing recombinant gonadotropin-based hormone therapies for increasing fertility in the flatfish Senegalese sole. PLoS ONE. 2017;12:e0174387 pubmed publisherNeckel P, Mattheus U, Hirt B, Just L, Mack A. Large-scale tissue clearing (PACT): Technical evaluation and new perspectives in immunofluorescence, histology, and ultrastructure. Sci Rep. 2016;6:34331 pubmed publisherMetzger J, Matsoff H, Zinnen A, Fleddermann R, Bondarenko V, Simmons H, et al. Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration. PLoS ONE. 2020;15:e0226999 pubmed publisherPechriggl E, Bitsche M, Glueckert R, Rask Andersen H, Blumer M, Schrott Fischer A, et al. Development of the innervation of the human inner ear. Dev Neurobiol. 2015;75:683-702 pubmed publisherJohnson Chacko L, Pechriggl E, Fritsch H, Rask Andersen H, Blumer M, Schrott Fischer A, et al. Neurosensory Differentiation and Innervation Patterning in the Human Fetal Vestibular End Organs between the Gestational Weeks 8-12. Front Neuroanat. 2016;10:111 pubmedMaleszewski J, Larsen B, Kip N, Castonguay M, Edwards W, Carney J, et al. PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors. Am J Surg Pathol. 2014;38:1079-87 pubmed publisherSousa S, Gomez R, Diniz M, Bernardes V, Soares F, Brito J, et al. Defects of the Carney complex gene (PRKAR1A) in odontogenic tumors. Endocr Relat Cancer. 2015;22:399-408 pubmed publisherPeter C, Saito A, Hasegawa Y, Tanaka Y, Nagpal M, Perez G, et al. In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene. Nat Commun. 2019;10:4112 pubmed publisherMeng F, Qian M, Peng B, Peng L, Wang X, Zheng K, et al. Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice. elife. 2020;9: pubmed publisherKim M, Jeong J, Seo J, Kim H, Kim S, Jin W. Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer. Sci Rep. 2016;6:33899 pubmed publisherCoccia E, Planells Ferrer L, Badillos Rodríguez R, Pascual M, Segura M, Fernández Hernández R, et al. SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. Cell Death Dis. 2020;11:82 pubmed publisherZykova T, Zhu F, Wang L, Li H, Bai R, Lim D, et al. The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis. EBioMedicine. 2017;18:73-82 pubmed publisherBlomfield I, Rocamonde B, Masdeu M, Mulugeta E, Vaga S, van den Berg D, et al. Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells. elife. 2019;8: pubmed publisherSkieterska K, Rondou P, Lintermans B, Van Craenenbroeck K. KLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant. PLoS ONE. 2015;10:e0145654 pubmed publisherEichner R, Heider M, Fernández Sáiz V, van Bebber F, Garz A, Lemeer S, et al. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Nat Med. 2016;22:735-43 pubmed publisherZhou X, Wei J, Chen F, Xiao X, Huang T, He Q, et al. Epigenetic downregulation of the ISG15-conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma. Oncotarget. 2015;6:41077-91 pubmed publisherKyei G, Meng S, Ramani R, Niu A, Lagisetti C, Webb T, et al. Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency. MBio. 2018;9: pubmed publisherJoo H, Yun M, Jeong J, Park E, Shin H, Woo S, et al. SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia. Biochem Biophys Res Commun. 2015;462:294-300 pubmed publisherLi F, Li Z, Jiang Z, Tian Y, Wang Z, Yi W, et al. Enhancement of early cardiac differentiation of dedifferentiated fat cells by dimethyloxalylglycine via notch signaling pathway. Am J Transl Res. 2016;8:4791-4801 pubmedSaito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, et al. Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. Eur J Immunol. 2015;45:2028-41 pubmed publisherHuang K, Chen Z, Jiang Y, Akare S, Kolber Simonds D, Condon K, et al. Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61. Mol Cancer Ther. 2016;15:1208-16 pubmed publisherHung M, Chen Y, Chu P, Shih C, Yu H, Tai W, et al. Upregulation of the oncoprotein SET determines poor clinical outcomes in hepatocellular carcinoma and shows therapeutic potential. Oncogene. 2016;35:4891-902 pubmed publisherMartin Almedina S, Martínez Corral I, Holdhus R, Vicente A, Fotiou E, Lin S, et al. EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. J Clin Invest. 2016;126:3080-8 pubmed publisherGrau C, Arató K, Fernández Fernández J, Valderrama A, Sindreu C, Fillat C, et al. DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors. Front Cell Neurosci. 2014;8:331 pubmed publisherGlenewinkel F, Cohen M, King C, Kaspar S, Bamberg Lemper S, Mymryk J, et al. The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Sci Rep. 2016;6:28241 pubmed publisherMorlé A, Garrido C, Micheau O. Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. Cell Death Dis. 2015;6:e1633 pubmed publisherSchwenk J, Pérez Garci E, Schneider A, Kollewe A, Gauthier Kemper A, Fritzius T, et al. Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics. Nat Neurosci. 2016;19:233-42 pubmed publisherLautz J, Brown E, Williams VanSchoiack A, Smith S. Synaptic activity induces input-specific rearrangements in a targeted synaptic protein interaction network. J Neurochem. 2018;146:540-559 pubmed publisherBrown E, Lautz J, Davis T, Gniffke E, VanSchoiack A, Neier S, et al. Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models. Mol Autism. 2018;9:48 pubmed publisherCaohuy H, Yang Q, Eudy Y, Ha T, Xu A, Glover M, et al. Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regulat. J Biol Chem. 2014;289:35953-68 pubmed publisherPhilippe R, Antigny F, Buscaglia P, Norez C, Becq F, Frieden M, et al. SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells. Biochim Biophys Acta. 2015;1853:892-903 pubmed publisherCanu N, Pagano I, La Rosa L, Pellegrino M, Ciotti M, Mercanti D, et al. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Front Mol Neurosci. 2017;10:15 pubmed publisherLundgren J, Vandermeulen L, Sandebring Matton A, Ahmed S, Winblad B, Di Luca M, et al. Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain. BMC Neurosci. 2020;21:6 pubmed publisherDumas A, Lê Bury G, Marie Anaïs F, Herit F, Mazzolini J, Guilbert T, et al. The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking. J Cell Biol. 2015;211:359-72 pubmed publisherFrolikova M, Sebkova N, Ded L, Dvorakova Hortova K. Characterization of CD46 and ?1 integrin dynamics during sperm acrosome reaction. Sci Rep. 2016;6:33714 pubmed publisherLaporte A, Ji J, Ma L, Nielsen T, Brodin B. Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay. Oncotarget. 2016;7:34384-94 pubmed publisherLaporte A, Barrott J, Yao R, Poulin N, Brodin B, Jones K, et al. HDAC and Proteasome Inhibitors Synergize to Activate Pro-Apoptotic Factors in Synovial Sarcoma. PLoS ONE. 2017;12:e0169407 pubmed publisherHarley M, Murina O, Leitch A, Higgs M, Bicknell L, Yigit G, et al. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nat Genet. 2016;48:36-43 pubmed publisherMargalef P, Kotsantis P, Borel V, Bellelli R, Panier S, Boulton S. Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe. Cell. 2018;172:439-453.e14 pubmed publisherSpurlock C, Tossberg J, Guo Y, Collier S, Crooke P, Aune T. Expression and functions of long noncoding RNAs during human T helper cell differentiation. Nat Commun. 2015;6:6932 pubmed publisherXiao T, Liu L, Li H, Sun Y, Luo H, Li T, et al. Long Noncoding RNA ADINR Regulates Adipogenesis by Transcriptionally Activating C/EBPα. Stem Cell Reports. 2015;5:856-65 pubmed publisherMarnef A, Jády B, Kiss T. Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol. Nucleic Acids Res. 2016;44:1342-53 pubmed publisherZhang L, Yang Z, Trottier J, Barbier O, Wang L. Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay. Hepatology. 2017;65:604-615 pubmed publisherZhu C, Chen C, Huang J, Zhang H, Zhao X, Deng R, et al. SUMOylation at K707 of DGCR8 controls direct function of primary microRNA. Nucleic Acids Res. 2015;43:7945-60 pubmed publisherQi Y, Yu J, Han W, Fan X, Qian H, Wei H, et al. A splicing isoform of TEAD4 attenuates the Hippo-YAP signalling to inhibit tumour proliferation. Nat Commun. 2016;7:ncomms11840 pubmed publisherDERY K, Kujawski M, Grunert D, Wu X, Ngyuen T, Cheung C, et al. IRF-1 regulates alternative mRNA splicing of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in breast epithelial cells generating an immunoreceptor tyrosine-based inhibition motif (ITIM) containing isoform. Mol Cancer. 2014;13:64 pubmed publisherSundararaman B, Zhan L, Blue S, Stanton R, Elkins K, Olson S, et al. Resources for the Comprehensive Discovery of Functional RNA Elements. Mol Cell. 2016;61:903-13 pubmed publisherGolenberg N, Squirrell J, Bennin D, Rindy J, Pistono P, Eliceiri K, et al. Citrullination regulates wound responses and tissue regeneration in zebrafish. J Cell Biol. 2020;219: pubmed publisherYamamoto K, Venida A, Yano J, Biancur D, Kakiuchi M, Gupta S, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020;581:100-105 pubmed publisherShen H, Gan P, Wang K, Darehzereshki A, Wang K, Kumar S, et al. Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling. elife. 2020;9: pubmed publisherLochab S, Singh Y, Sengupta S, Nandicoori V. Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome. elife. 2020;9: pubmed publisherCupo R, Shorter J. Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations. elife. 2020;9: pubmed publisherChen J, Liu X, Ke K, Zou J, Gao Z, Habuchi T, et al. LINC00992 contributes to the oncogenic phenotypes in prostate cancer via targeting miR-3935 and augmenting GOLM1 expression. BMC Cancer. 2020;20:749 pubmed publisherGersch M, Wagstaff J, Toms A, Graves B, Freund S, Komander D. Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity. Mol Cell. 2019;74:436-451.e7 pubmed publisherHyle J, Zhang Y, Wright S, Xu B, Shao Y, Easton J, et al. Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping. Nucleic Acids Res. 2019;: pubmed publisherKornberg M, Bhargava P, Kim P, Putluri V, Snowman A, Putluri N, et al. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science. 2018;360:449-453 pubmed publisherGhezzi C, Wong A, Chen B, Ribalet B, Damoiseaux R, Clark P. A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. Nat Commun. 2019;10:5444 pubmed publisherOh S, Kim J, Park S, Lee J. Associative Interactions among Zinc, Apolipoprotein E, and Amyloid-β in the Amyloid Pathology. Int J Mol Sci. 2020;21: pubmed publisherTambini M, Norris K, D ADAMIO L. Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation. elife. 2020;9: pubmed publisherWang Y, Qiu W, Liu N, Sun L, Liu Z, Wang S, et al. Forkhead box K1 regulates the malignant behavior of gastric cancer by inhibiting autophagy. Ann Transl Med. 2020;8:107 pubmed publisherXiang Q, Wu M, Zhang L, Fu W, Yang J, Zhang B, et al. Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury. Front Pharmacol. 2020;11:452 pubmed publisherTan S, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, et al. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Cell. 2017;169:1105-1118.e15 pubmed publisherBigenzahn J, Collu G, Kartnig F, Pieraks M, Vladimer G, Heinz L, et al. LZTR1 is a regulator of RAS ubiquitination and signaling. Science. 2018;362:1171-1177 pubmed publisherMerrill N, Schipper J, Karnes J, Kauffman A, Martin K, Mackeigan J. PI3K-C2? knockdown decreases autophagy and maturation of endocytic vesicles. PLoS ONE. 2017;12:e0184909 pubmed publisherWang S, Ni H, Chao X, Wang H, Bridges B, Kumer S, et al. Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis. Autophagy. 2019;15:1954-1969 pubmed publisherYagensky O, Kohansal Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, et al. Increased expression of heme-binding protein 1 early in Alzheimer\'s disease is linked to neurotoxicity. elife. 2019;8: pubmed publisherSclip A, Sudhof T. LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses. elife. 2020;9: pubmed publisherTaura M, Song E, Ho Y, Iwasaki A. Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat. Proc Natl Acad Sci U S A. 2019;116:2282-2289 pubmed publisherMajer O, Liu B, Woo B, Kreuk L, Van Dis E, Barton G. Release from UNC93B1 reinforces the compartmentalized activation of select TLRs. Nature. 2019;575:371-374 pubmed publisherTurkington H, Juozapaitis M, Tsolakos N, Corrales Aguilar E, Schwemmle M, Hale B. Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins. J Virol. 2018;92: pubmed publisherJiang S, Athanasopoulos V, Ellyard J, Chuah A, Cappello J, Cook A, et al. Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus. Nat Commun. 2019;10:2201 pubmed publisherChittoor Vinod V, Lee S, Judge S, Notterpek L. Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22. ASN Neuro. 2015;7: pubmed publisherAzkanaz M, Rodríguez López A, de Boer B, Huiting W, Angrand P, Vellenga E, et al. Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock. elife. 2019;8: pubmed publisherOh E, Kim J, Kim J, Kim S, Lee J, Hong S, et al. NQO1 inhibits proteasome-mediated degradation of HIF-1α. Nat Commun. 2016;7:13593 pubmed publisherLabrousse Arias D, Martínez Alonso E, Corral Escariz M, Bienes Martínez R, Berridy J, Serrano Oviedo L, et al. VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1. J Cell Biol. 2017;216:835-847 pubmed publisherTorres A, Vargas Y, Uribe D, Jaramillo C, Gleisner A, Salazar Onfray F, et al. Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells. Oncotarget. 2016;7:67373-67386 pubmed publisherZhang C, Mukherjee S, Tucker Burden C, Ross J, Chau M, Kong J, et al. TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3. Mol Oncol. 2017;11:280-294 pubmed publisherTorres M, Pandita R, Kulak O, Kumar R, Formstecher E, Horikoshi N, et al. Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Mol Cell Biol. 2015;35:3633-45 pubmed publisherHansen R, Mund A, Poulsen S, Sandoval M, Klement K, Tsouroula K, et al. SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Nat Cell Biol. 2016;18:1357-1366 pubmed publisherPal S, Graves H, Ohsawa R, Huang T, Wang P, Harmacek L, et al. The Commercial Antibodies Widely Used to Measure H3 K56 Acetylation Are Non-Specific in Human and Drosophila Cells. PLoS ONE. 2016;11:e0155409 pubmed publisherPerez Leal O, Barrero C, Merali S. Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. J Biol Chem. 2017;292:14108-14121 pubmed publisherSharma S, Patnaik S, Kemer Z, Baysal B. Transient overexpression of exogenous APOBEC3A causes C-to-U RNA editing of thousands of genes. RNA Biol. 2017;14:603-610 pubmed publisherWei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisherChien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisherLin C, Lin W, Cho R, Yang C, Yeh Y, Hsiao L, et al. Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation. J Clin Med. 2020;9: pubmed publisherKaur A, Elzagheid A, Birkman E, Avoranta T, Kytölä V, Korkeila E, et al. Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer. Cancer Med. 2015;4:1798-808 pubmed publisherFrank T, Tuppi M, Hugle M, Dötsch V, van Wijk S, Fulda S. Cell cycle arrest in mitosis promotes interferon-induced necroptosis. Cell Death Differ. 2019;: pubmed publisherLópez J, González A. Organization of the catecholaminergic systems in the brain of lungfishes, the closest living relatives of terrestrial vertebrates. J Comp Neurol. 2017;525:3083-3109 pubmed publisherPrincely Abudu Y, Pankiv S, Mathai B, Håkon Lystad A, Bindesbøll C, Brenne H, et al. NIPSNAP1 and NIPSNAP2 Act as \"Eat Me\" Signals for Mitophagy. Dev Cell. 2019;49:509-525.e12 pubmed publisherKarimi Ashtiyani R, Ishii T, Niessen M, Stein N, Heckmann S, Gurushidze M, et al. Point mutation impairs centromeric CENH3 loading and induces haploid plants. Proc Natl Acad Sci U S A. 2015;112:11211-6 pubmed publisherMa W, Schubert V, Martis M, Hause G, Liu Z, Shen Y, et al. The distribution of ?-kleisin during meiosis in the holocentromeric plant Luzula elegans. Chromosome Res. 2016;24:393-405 pubmed publisherChaudhury A, Cheema S, Fachini J, Kongchan N, Lu G, Simon L, et al. CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT. Nat Commun. 2016;7:13362 pubmed publisherWongpalee S, Vashisht A, Sharma S, Chui D, Wohlschlegel J, Black D. Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing. elife. 2016;5: pubmed publisherCantuti Castelvetri L, Ojha R, Pedro L, Djannatian M, Franz J, Kuivanen S, et al. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020;: pubmed publisherNordmann G, Malkemper E, Landler L, Ushakova L, Nimpf S, Heinen R, et al. A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves. Sci Rep. 2020;10:915 pubmed publisherXie C, Wang R, Saeed A, Yang Q, Chen H, Ling S, et al. Preparation of Anti-Human Podoplanin Monoclonal Antibody and its application in Immunohistochemical Diagnosis. Sci Rep. 2018;8:10162 pubmed publisherLerner E, Lerner M, Janeway C, Steitz J. Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc Natl Acad Sci U S A. 1981;78:2737-41 pubmedElTanbouly M, Zhao Y, Nowak E, Li J, Schaafsma E, Le Mercier I, et al. VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance. Science. 2020;367: pubmed publisher. Golgin A4 in CSF and granulovacuolar degenerations of patients with Alzheimer disease. Neurology. 2018;91:e1799-e1808 pubmed publisherHe D, Fan X, Liu B, Tian Y, Zhang X, Kang L, et al. Generation and characterization of a IgG monoclonal antibody specific for GM3 (NeuGc) ganglioside by immunizing β3Gn-T5 knockout mice. Sci Rep. 2018;8:2561 pubmed publisherArboleda Velasquez J, Lopera F, O Hare M, Delgado Tirado S, Marino C, Chmielewska N, et al. Resistance to autosomal dominant Alzheimer\'s disease in an APOE3 Christchurch homozygote: a case report. Nat Med. 2019;: pubmed publisherOuadah Y, Rojas E, Riordan D, Capostagno S, Kuo C, Krasnow M. Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch. Cell. 2019;179:403-416.e23 pubmed publisherYokota T, McCourt J, Ma F, Ren S, Li S, Kim T, et al. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. Cell. 2020;: pubmed publisherLee E, Liang Q, Ali H, Bayliss L, Beasley A, Bloomfield Gerdes T, et al. Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery. Nat Biotechnol. 2014;32:356-63 pubmed publisherMurphy A, Macdonald L, Stevens S, Karow M, Dore A, Pobursky K, et al. Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice. Proc Natl Acad Sci U S A. 2014;111:5153-8 pubmed publisherSkokos D, Waite J, Haber L, Crawford A, Hermann A, Ullman E, et al. A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies. Sci Transl Med. 2020;12: pubmed publisher